The Beta Cell Biology Consortium (BCBC) was a team science initiative that was established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It was initially funded in 2001 (RFA DK-01-014), and competitively continued both in 2005 (RFAs DK-01-17, DK-01-18) and in 2009 (RFA DK-09-011). Funding for the BCBC came to an end on August 1, 2015, and with it so did our ability to maintain active websites.
One of the many goals of the BCBC was to develop and maintain databases of useful research resources. A total of 813 different scientific resources were generated and submitted by BCBC investigators over the 14 years it existed. Information pertaining to 495 selected resources, judged to be the most scientifically-useful, has been converted into a static catalog, as shown below. In addition, the metadata for these 495 resources have been transferred to dkNET in the form of RDF descriptors, and all genomics data have been deposited to either ArrayExpress or GEO.
Please direct questions or comments to the NIDDK Division of Diabetes, Endocrinology & Metabolic Diseases (DEM).
The 495 selected resources are hoped to have a lasting and positive impact for the scientific community.
The following files capture key components of the content that was available on the BCBC site about Genomics Studies, Mouse Strains, Antibodies and ESC lines. These RDF files are instantiations in OWL2 of the Beta Cell Genomics Ontology (BCGO) based on the Ontology for Biomedical Investigations (OBI) standard. They can be browsed in OWL-compatible ontology editors (such as Protege) and searched via SPARQL queries. Competency questions used to motivate the structure of the files and validate their content are also provided. Provided SPARQL versions of the questions can be used to generate template queries.
The following listing contains antibodies, genomics studies, mouse ESC lines, and mouse strains. Other BCBC resource types have been permanently archived and are not represented in this resource.
ID | Resource | Type | Contact | Snapshot | External DB Link(s) |
---|---|---|---|---|---|
4626 | High-resolution DNase-seq profiles of targeted loci in mES-derived primitive ectoderm | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3497 |
4625 | Small RNA discovery in developing mouse and during human in vitro beta-cell differentiation protocol | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3489 |
4624 | DNase-seq profile of E11.5 whole mouse embryos | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3468 |
4623 | DNase-seq profile of mES cells treated with PFA/Noco/5aza, at different timepoints within in vitro mouse differentiation protocols, or in the presence of a NFYA dominant negative construct | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3465 |
4622 | DNase-seq profile of human islet and in vitro differentiation-derived Pdx1+ cells | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3432 |
4621 | RNA-seq of Ins+ cells in human differentiation protocol across lines and isolated from human islets | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3429 |
4620 | RNA-seq comparison: before/after MARIS protocol and library construction technique test | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3424 |
4619 | RNA-seq of Ins+, Ucn3+/- cell populations within developmental mouse islets using MARIS | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3418 |
4618 | RNA-seq of Pdx1+ mouse Islet during development | Genomics Study | Doug Melton Harvard / HHMI |
View PDF | ArrayExpress - E-MTAB-3417 |
4617 | WT vs Nkx2.2-/- (null) cells at E15.5 | Genomics Study | Lori Sussel Columbia University |
View PDF | ArrayExpress - E-MTAB-3357 |
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